POSTDOCTORAL FELLOW

We are recruiting postdocs with diverse backgrounds and expertise to work at the forefront of tumor immunology and neuro-immune crosstalk. Multiple postdoctoral fellow positions are immediately available.

Research Area:

The immune system is not only essential for host defense against pathogens, but also plays critical roles in regulating tissue homeostasis in response to various environmental or genotoxic insults. Our previous work has demonstrated the diverse functions and mechanisms by which different immune cell types and pathways interact with the commensal microbiota or the nervous system in the context of metabolic diseases (Nature, 2020; Nature, 2012;), tissue injury (Science, 2016; PNAS, 2011), and particularly in cancer (Cell, 2019; Nature Reviews Cancer, 2013).

Current research in our lab is focused on studying how host-intrinsic factors (e.g. the nervous system, genetic/epigenetic alterations in cancer cells) or environmental cues (e.g. microbiota) reprogram the immune cells in the tumor microenvironment (TME), with the ultimate goal to convert the “cold” tumors to “hot” tumors to improve immunotherapies. We are combining unique genetically engineered mouse models with state-of-the art technologies including single-cell based multi-omics, advanced imaging, in vivo CRIPSR-based genome editing. Specific projects involve (1) novel myeloid subsets in “hot” and “cold” tumors, (2) neuro-immune interaction in the lung, (3) innate immune sensing in the TME, (4) the gut-lung axis, (5) CRISPR screen of novel molecular targets for tumor immunotherapy. The lab is well-funded with superb resources, including unique germ-free genetic mouse models.

Candidates should have Ph.D., M.D., or equivalent degrees. Previous research experience in cancer biology, immunology, mouse genetics, microbiology, bioinformatics or related areas are preferred, but not required. Please email your CV, a brief description of your previous work and your future research interests and arrange for 3 letters of recommendation to be sent to chengcheng.jin@pennmedicine.upenn.edu if interested.

GRADUATE STUDENT

We are accepting rotation students from all Biomedical Graduate Studies (BGS) programs at Penn. If you are interested in learning more about the potential rotation projects, please email chengcheng.jin@pennmedicine.upenn.edu to discuss.

RESEARCH TECHNICIAN

We are seeking a motivated, highly organized team player with strong interpersonal and communication skills to support our exciting research in cancer immunology. A bachelor’s degree in biological sciences, working knowledge of molecular biology and genetics, and experience in the ethical and humane use of animals (especially mice) in laboratory research are preferred.

The research technician/associate will work under the direct supervision and close mentorship of the PI, assisting in experimental animal model systems, conducting various lab experiments, performing prep work for experiments, conducting standard lab techniques, and functioning to support lab and/or research project or protocol. Duties will include animal husbandry, PCR ­based genotyping, and in vivo tumor imaging (bioluminescence and micro computed tomography); the preparation/analysis of histopathological samples; cell culture; flow cytometry; DNA, RNA, and protein isolation and detection techniques; and general lab support and assistance with research experiments.

The Jin lab will provide an excellent training opportunities to promote career development to graduate school or medical school.